Immune Resilience and Immortality

ONOGEN
7 min readOct 1, 2021

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ONOGEN

In 2015 according to WHO global life expectancy at birth averaged 69 to 73 years, with females living longer than males. People say, oh, I don’t want to live past 90 but you know, I talk to 90-year-olds, and they definitely want to live to 91 and even to 100. “People sometimes say that death gives meaning to life because it makes time short, but death is a great robber of meaning, of relationships, of knowledge.” We’re going to be able to overcome disease and aging, most of our thinking will be nonbiological, that will be backed up, so part of it gets wiped away, you can recreate it. We will be able to extend our lives indefinitely.

The normal human lifespan is about 125 years according to Grossman and other singularitarians, immortality will arrive in stages. The stages of immortality start from the first, being a lifestyle and aggressive antiaging therapies will allow more people to approach the 125-year limit of the natural human lifespan, this is bridge one.

Meanwhile, advanced medical technology will begin to fix some of the underlying biological causes of aging, allowing this natural limit to be surpassed, this is bridge two. Finally, computers have become so powerful that they can model human consciousness. This will permit us to download our personalities into nonbiological substrates. When we cross this third bridge, we become information, and then, as long as we maintain multiple copies of ourselves to protect against a system crash, we won’t die.

What is Immunosenescence?

While people’s expectations are moving way up to futuristic concepts such as living up to 142 and immortality are emerging and becoming possible achievable options. So going to immunosenescence and what I was talking about your telomeres shortening, and after your telomeres get shorter and your DNA methylation change, your immune system has started declining and immune sentencing has been leading to degenerative brain issues to degenerative arthritis, to chronic inflammation to heart disease to increase mortality with COVID and different infections.

Weakened immune statuses are considered part of the normal natural aging process. However, through COVID, we found out that some people were 70 years old in their immune status while some people would be 40 and dying during the pandemic. If we blame genetics for that, we find that just less than 5% of the cases were genetic related, and more of those cases were epigenetics, so our immune system ages, but we can only control a certain level of it. That control is where we have understood that data is where we are going to empower patients to understand the process and make the decisions and the choices, they need to make to overcome those health obstacles. There is an amazing study that highlights data about the memory of the timers on the immune system and the memory of the immune system is affected by immune resilience, which is interconnected to immunosenescence from our lifespan.

Immune Status

The big immune system problem is more visible when people become 60 and older. That is what we saw rapidly during COVID. However, we know that there are some people younger than 60, that might see a decline in their immune status earlier. Usually, the decline is related to stress, smoking, toxicity, environmental toxins, and multi-risk factors that epigenetically affect our telomeres, our DNA methylation, and eventually, our whole immune system which accelerating aging.

Biohacking Blog | ONOGEN

Also known as inflammaging, a key factor known to affect how well a person ages depending if their inflammaging levels are low or high, low being the optimal side. As soon as the immune system starts aging, we start aging with it. The main thing that I want people to focus on here is naive cells are yellow, the gene is orange, the right side has the killer cells. That is where the stem cells are labeled as the helper cells and the killer cells are the cells that kill cancer and kill viruses, especially new things that are coming to your body.

As you can see in the graphic after 60 the population of those cells declined. This is where we see the major hit, however, we also see that between 20 to 60, there is a fall in those numbers too, because people who are younger than 20 have 50 helper cells. Then it comes down to 29, which is almost half, most of that drop happens around 40. After 40, it depends literally on epigenetic factors. So, if you have a healthy lifestyle, you eat healthily, you do not smoke, your chances to have a younger immune system are more resilient. One of the things that I have noticed in moods is that happy people have a happy immune system, and a happy immune system is more resistant. Which in turn happened to be true, it has been proven in multiple studies alongside the data my company has collected in our study as well.

A Patient-Centred Medical Model

I was motivated to bring an empathetic approach to medicine, I was going to change the genes of everyone in my practice. So I analyzed my own nutrient levels and started making changes, to feel better, and then I did feel better while I was aging and that’s when I coined the term for my book “beyond well”. I noticed that I started sharing more recommendations with my patients and testing them, what I thought they needed based on their functional analysis and their symptoms. When analyzing their emotional health aka mind-body health I saw their telomere lengths improved remarkably, which resulted in a rapid impact on their genes which increased the likelihood of having a healthier aging process. By seeing the vast change and seeing my patients evolve to healthy longevity simply by changing my medical methodology and deep diving into understanding the science and impact of telomeres on your whole body was change-making for my practice.

The business of longevity isn’t easy, it’s not easy to reach a point to give your patient options like having a lower risk of cancer, a lowefr risk of Alzheimer’s, lower risk of dementia because of telomere lengthening is linked to all those things. Enhancing of the micronutrient environment is important for public health too because it enhances your natural stem cell function and your immune system and with that, you get your system working for you at its highest potential.

Empathy In Medicine

All major schools in America are now opening empathetic kindness, departments of compassion. We are teaching people to be kind and compassionate, which is kind of funny because we should learn that at home or school before we get to the university. But I do think that the whole science is so amazing into kindness and passion, compassion, and love. That as we learn more and more, we understand how important is to not underestimate emotions, in our care and our daily living.

My main work in the last few years is to empower patients, to make them motivated towards what they need to do in life. Markers are things, I think they are so important, so, I have been creating different algorithms to bring up complex data and make that data translated into a number that patients can understand. Biological age has been around but not many people have advanced the use of this data, In the last two years, I decided to move my research to immunity age, because I saw that the immunosenescence was synergetic with the power of stem cells.

Modernizing Healthcare

The pandemic has impacted the way that patients see the medical system and want to interact with the system. For a while, we have been talking about predictive medicine because we have genetic health options now and people understand that they can get these services now than they could before due to traditional medical models. We now need to open more space for a system that is more empathetic, more proactive, and more inclusive, as artificial intelligence advances too. Humanizing healthcare is the first step then to teach artificial intelligence to bring the human side of medicine to modern medicine which will create the future of medicine.

For example if a patient’s calm, and their 45, they come to me and I see their numbers, and I say yeah, your kidneys, your heart, everything is working, is nothing is failing, you’re good, they’re just going to continue with their life, and they’re not going to feel like they need to change anything, because the markers look like he’s they’re doing okay.

I would never force changes their bodies are already optimized, some want to reach health optimization on higher levels and that’s where our protocols come in: PRIME | ONOGEN the more committed they are to creating changes, the more meaningful their medical experience turns out to be. We’ve accepted innovation and are redefining treatments to humanize healthcare.

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ONOGEN is a biotech startup delivering personalized biomolecular medicine by renovating healthcare and the existing medical model.